Direct thrombolytic therapy for superior sagittal sinus thrombosis.

Dural venous sinus thrombosis (DVST) in the neonatal period has a spectrum of clinical and radiologic findings. At the present time, the treatment for venous sinus thrombosis is mainly one of supportive therapy. In a patient with documented DVST, whose clinical status is deteriorating despite conventional supportive therapy, there may be a rationale for more aggressive therapy. We report a case of DVST that was successfully managed by direct puncture of the superior sagittal sinus and infusion of urokinase, resulting in clot lysis over 12 hr.